Journal
INFECTION GENETICS AND EVOLUTION
Volume 85, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2020.104500
Keywords
Haemonchus contortus; Developmental biology; Drug resistance; Integrative 'omics; Parasitism
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Funding
- Australian Research Council (ARC)
- National Health and Medical Research Council (NHMRC) of Australia
- BGI International Pty Ltd
- Yourgene Health, Melbourne Water
- ARC [LP180101334, LP180101085]
- NHMRC Career Development Fellowship
- NHMRC Early Career Research Fellowship
- Australian Research Council [LP180101334] Funding Source: Australian Research Council
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Advances in nucleic acid sequencing, mass spectrometry and computational biology have facilitated the identification, annotation and analysis of genes, transcripts, proteins and metabolites in model nematodes (Caenorhabditis elegans and Pristionchus pacificus) and socioeconomically important parasitic nematodes (Clades I, III, IV and V). Significant progress has been made in genomics and transcriptomics as well as in the proteomics and lipidomics of Haemonchus contortus (the barber's pole worm) - one of the most pathogenic representatives of the order Strongylida. Here, we review salient aspects of genomics, transcriptomics, proteomics, lipidomics, glycomics and functional genomics, and discuss the rise of integrative 'omics of this economically important parasite. Although our knowledge of the molecular biology, genetics and biochemistry of H. contortus and related species has progressed significantly, much remains to be explored, particularly in areas such as drug resistance, unique/unknown genes, host-parasite interactions, parasitism and the pathogenesis of disease, by integrating the use of multiple 'omics methods. This approach should lead to a better understanding of H. contortus and its relatives at a 'systems biology' level, and should assist in developing new interventions against these parasites.
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