Journal
INFECTION GENETICS AND EVOLUTION
Volume 82, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2020.104285
Keywords
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Genome; Genetic evolution; Structural protein; 2019 Coronavirus disease (COVID-19)
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Funding
- National Key Research and Development Program of China [2017YFD0500103]
- National Natural Science Foundation of China [31772747]
- Science and Technology Research Program during the 13th Five-Year Plan Period of Jilin Educational Committee [JJKH20190172KJ]
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The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is a Public Health Emergency of International Concern. However, so far, there are still controversies about the source of the virus and its intermediate host. Here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including Paguma larvata, Paradoxurus hermaphroditus, Civet, Aselliscus stoliczkanus and Rhinolophus sinicus, and was in the same branch of the phylogenetic tree. However, genome and ORF1a homology show that the virus is not the same coronavirus as the coronavirus derived from these five animals, whereas the virus has the highest homology with Bat coronavirus isolate RaTG13.
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