Journal
IMMUNOLOGICAL REVIEWS
Volume 297, Issue 1, Pages 123-138Publisher
WILEY
DOI: 10.1111/imr.12908
Keywords
disease; GSDMD; IL-1; immunotherapy; inflammasome; inflammation; NLRP3; pyroptosis
Categories
Funding
- European Research Council [683144]
- European Research Council (ERC) [683144] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Inflammasomes are macromolecular complexes formed in response to pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) that drive maturation of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18, and cleave gasdermin D (GSDMD) for induction of pyroptosis. Inflammasomes are highly important in protecting the host from various microbial pathogens and sterile insults. Inflammasome pathways are strictly regulated at both transcriptional and post-translational checkpoints. When these checkpoints are not properly imposed, undue inflammasome activation may promote inflammatory, metabolic and oncogenic processes that give rise to autoinflammatory, autoimmune, metabolic and malignant diseases. In addition to clinically approved IL-1-targeted biologics, upstream targeting of inflammasome pathways recently gained interest as a novel pharmacological strategy for selectively modulating inflammasome activation in pathological conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available