4.6 Article

Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells

Journal

IEEE TRANSACTIONS ON ELECTRON DEVICES
Volume 67, Issue 8, Pages 3355-3361

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TED.2020.3002498

Keywords

Acoustic tweezer; cell manipulation; gallium nitride (GaN); surface acoustic wave (SAW)

Funding

  1. Natural Science Foundation of China [81501472, 61704017]
  2. Engineering and Physical Sciences Research Council (EPSRC) [EP/N01202X/2, EP/P002803/1, EP/P018998/1]
  3. Global Challenges Research Fund (GCRF)
  4. Royal Society [IEC/NSFC/170142, IE161019]
  5. Natural Science Basic Research Program of Shaanxi Province [2020JQ-233]
  6. EPSRC [EP/N01202X/2, EP/P018998/1, 2117761, EP/P002803/1] Funding Source: UKRI

Ask authors/readers for more resources

Gallium nitride (GaN) is a compound semiconductor which has advantages to generate new functionalities and applications due to its piezoelectric, pyroelectric, and piezo-resistive properties. Recently, surface acoustic wave (SAW)-based acoustic tweezers were developed as an efficient and versatile tool to manipulate nano- and microparticles aiming for patterning, separating, and mixing biological and chemical components. Conventional piezoelectric materials to fabricate SAW devices such as lithium niobate suffer from its low thermal conductivity and incapability of fabricating multiphysical and integrated devices. This article piloted the development of a GaN-based acoustic tweezer (GaNAT) and its application in manipulating microparticles and biological cells. For the first time, the GaN SAW device was integrated with a microfluidic channel to form an acoustofluidic chip for biological applications. The GaNAT demonstrated its ability to work on high power (up to 10 W) with minimal cooling requirement while maintaining the device temperature below 32 degrees C. Acoustofluidic modeling was successfully applied to numerically study and predict acoustic pressure field and particle trajectories within the GaNAT, which agree well with the experimental results on patterning polystyrene microspheres and two types of biological cells including fibroblast and renal tumor cells. The GaNAT allowed both cell types to maintain high viabilities of 84.5% and 92.1%, respectively.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available