Journal
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
Volume 67, Issue 6, Pages 1542-1547Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBME.2019.2939560
Keywords
Probes; Optical fiber sensors; Optical fibers; Nanoparticles; Silver; Biomedical optical imaging; Dopamine; tapered optical fiber; silver nanoparticles; polyethylene glycol; localized surface plasmon resonance
Categories
Funding
- National Key Research & Development Program of China [2016YFB0402105]
- Belt and Road Special Project
- Liaocheng University, China [31805180301, 31805180326]
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This article presents a localized surface plasmon resonance (LSPR) phenomenon based optical fiber sensor (OFS) for the detection of dopamine (DA). DA functions as a hormone and a neurotransmitter in the human body and plays a crucial role in the peripheral system. To develop the OFS for DA detection, taper fiber probe was fabricated and immobilized with silver nanoparticles (AgNPs) and functionalized with Polyethylene glycol (PEG). The developed sensor shows the great selectivity in the presence of ascorbic acid (AA) oxidation due to PEG coating. The morphology of the AgNPs and uniformity of coating over the surface of sensing probe were confirmed with UV-visible spectrophotometer, transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS), and scanning electron microscope (SEM). The calibration curve is found to be linear over the range of 10 nM-1 mu M with the lowest detection limit of 0.058 mu M. Also provides a wide dynamic range of detection (10 nm-100 mu M). The parameters responsible for the performance of OFS, such as sensitivity, detection limit, and selectivity are greatly improved in the proposed sensor. The applicability of the proposed sensor has been validated and have the potential to use for routine diagnosis.
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