Journal
CLINICA CHIMICA ACTA
Volume 453, Issue -, Pages 28-37Publisher
ELSEVIER
DOI: 10.1016/j.cca.2015.11.028
Keywords
Saliva; Renal failure; Nephropathy; Biomarkers; Urea
Categories
Funding
- Ministry of Education, Science, Research and Sport of the Slovak Republic [VEGA 1/0172/14, VEGA 1/0222/14]
- German Research Foundation (Deutsche Forschungsgemeinschaft - DFG) [SFB/TRR, BO 3755/2-1]
- German Federal Ministry of Education and Research [BMBF 01GM1518A]
- Else-Kroner Fresenius Stiftung [EKFS 2012_A216]
- Interdisciplinary Centre for Clinical Research within the Faculty of Medicine at the RWTH Aachen University [K7-3]
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Saliva can be collected non-invasively, repeatedly and without trained personnel. It is a promising diagnostic body fluid with clinical use in endocrinology and dentistry. For decades, it is known that saliva contains also urea, creatinine and other markers of renal function. Clinical studies have shown that the salivary concentrations of these markers could be useful for the assessment of kidney function without the need of blood collection. This article summarizes the clinical and experimental data on the use of saliva as a diagnostic fluid in nephrology and points out the advantages, pitfalls, technical requirements and future perspective for the use of saliva as a novel potential diagnostic biofluid. (C) 2015 Elsevier B.V. All rights reserved.
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