Journal
CLINICA CHIMICA ACTA
Volume 457, Issue -, Pages 27-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2016.03.016
Keywords
Autophagy; IVD; IDD; NP; AF
Categories
Funding
- National Natural Science Foundation of China [31570946]
- Natural Science Foundation of Hunan Province [2015JJ5003]
Ask authors/readers for more resources
Autophagy is a homeostatic mechanism through which intracellular damaged organelles and proteins are degraded and recycled in response to increased metabolic demands or stresses. Although primarily cytoprotective, dysfunction of autophagy is often associated with many degenerative diseases, including intervertebral disc (ND) degeneration (IDD). As a main contributing factor to low back pain, IDD is the pathological basis for various debilitating spinal diseases. Either higher or lower levels of autophagy are observed in degenerative IVD cells. Despite the precise role of autophagy in disc degeneration that is still controversial, with difference from protection to aggravation, targeting autophagy has shown promise for mitigating disc degeneration. In the current review, we summarize the changes of autophagy in degenerative ND cells and mainly discuss the relationship between autophagy and IDD. With continued efforts, modulation of the autophagic process could be a potential and attractive therapeutic strategy for degenerative disc disease. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available