Journal
CLINICA CHIMICA ACTA
Volume 456, Issue -, Pages 107-114Publisher
ELSEVIER
DOI: 10.1016/j.cca.2016.02.024
Keywords
Alzheimer's disease; A beta; Cholesterol; apoE; PCSK9; LRP1
Categories
Funding
- National Natural Science Foundation of China [81200217, 81370376]
- Key Project of Science and Technology Department of Hunan Province [2015JC3081]
- Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [CQKLBST-2014-002, CQKLBST-2015-004]
- Construct Program of the Key Discipline in Hunan Province [XJF-2011-76]
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Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease that is mainly caused by beta-amyloid accumulation. A large number of studies have shown that elevated cholesterol levels may perform a function in AD pathology, and several cholesterol-related gene polymorphisms are associated with this disease. Although numerous studies have shown the important function of cholesterol in AD pathogenesis and development, the underlying mechanism remains unclear. To further elucidate cholesterol metabolism disorder and AD, we first, review metabolism and regulation of the cholesterol in the brain. Second, we summarize the literature stating that hypercholesterolemia is one of the risk factors of AD. Third, we discuss the main mechanisms of abnormal cholesterol metabolism that increase the risk of AD. Finally, the relationships between AD and apolipoprotein E, PCSK9, and LRP1 are discussed in this article. (C) 2016 Elsevier B.V. All rights reserved.
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