Journal
CLINICA CHIMICA ACTA
Volume 453, Issue -, Pages 107-113Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2015.12.010
Keywords
Adropin; Atherosclerosis; Coronary artery disease; Heart failure; Hypertension
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Funding
- National Natural Sciences Foundation of China [81270269, 81370377]
- Zhengxiang Scholar Program of University of South China
- construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa) [[2011]76]
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Cardiovascular diseases, such as atherosclerosis and hypertension, are the major cause of mortality and morbidity in the world. Adropin was first discovered in 2008 by Kumar and his coworkers. Adropin, encoded by the Energy Homeostasis Associated gene, is expressed in many tissues and organs, such as pancreatic tissue, liver, brain, kidney, endocardium, myocardium, and epicardium. In this review, we have summarized recent data suggesting the roles of adropin in several major cardiovascular diseases. Increasing evidence suggests that adropin is a potential regulator of cardiovascular functions and plays a protective role in the pathogenesis and development of cardiovascular diseases. However, further studies are needed to elucidate the specific mechanisms underlying the association between adropin and cardiovascular diseases. (C) 2015 Elsevier B.V. All rights reserved.
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