Circulating omentin-1 levels and inflammation in polycystic ovary syndrome

Objectives:The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and inflammation in PCOS. Material and methods: A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-alpha, sTNFRs, IL-6 and sR-IL6 were measured in the fasting state. Results: Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin-1 levels was associated with PCOS occurrence, higher circulating TNF-alpha and lower IL-6 levels. Conclusions: Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines are factors modifying secretion of this adipokine.