Journal
FOOD REVIEWS INTERNATIONAL
Volume 38, Issue 6, Pages 1149-1165Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/87559129.2020.1771363
Keywords
Bioactivity; extraction; ginseng; polysaccharide; structural characterization
Categories
Funding
- National Natural Science Foundation of China [21502177]
- Youth Talents Project of Henan Province [2020HYTP046]
- Higher Education School Young Backbone Teacher Training Program of Henan Province [2018GGJS093]
- Basic Research Plan of Higher Education School Key Scientific Research Project of Henan Province [19zx012]
- Program for Science and Technology Innovation Talents in Universities of Henan Province [20HASTIT037]
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This review introduces the extraction, purification, characterization, and bioactivity of ginseng polysaccharides, and discusses the structure-bioactivity relationship.
Ginseng (Panax ginsengC. A. Meyer) is known as a valuable traditional Chinese herb for tens of centuries. Previous pharmacological and phytochemical investigations indicate that polysaccharides are a main biologically active ginseng component that possesses different bioactivities such as antitumor, immunoregulation, antioxidation, hepatoprotection, and anti-inflammation. Work is needed to summarize the full aspects of these polysaccharides systematically to boost their further investigation and application. In this review, studies on the extraction, purification, characterization, and bioactivity are introduced in detail. Moreover, the structure-bioactivity relationship of ginseng polysaccharides is explored and discussed. The uronic acids richer in ginseng polysaccharides tend to have higher biological effect, and the alpha-(1 -> 4)-GalpA and alpha-(1 -> 4)-Galpin the main chain are essential for the anti-inflammatory and antiviral effects. We believe our work proposes a helpful bibliography for further innovation and promotes these natural products in functional food.
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