Journal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Volume 16, Issue 8, Pages 703-709Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17425255.2020.1785429
Keywords
D-chiro-inositol; aromatase; estrogen; endometriosis; controlled ovarian hyperstimulation; male hypogonadism
Ask authors/readers for more resources
Introduction Inositols have a key role in ovarian physiology and the literature reports a wealth of studies about the major isomer, myo-inositol (MI). However, information aboutd-chiro-inositol (DCI) is still scarce, despite the ratio MI:DCI is tissue-specific and actively maintained by an insulin-dependent epimerase enzyme. Areas covered This expert opinion provides an overview of the physiological contribution of DCI in regulating steroidogenesis. DCI indeed mediates the intracellular signaling of insulin, which induces the biosynthesis of androgens. Studies on second messengers of insulin also revealed that DCI has a specific role in modulating the activity of aromatase enzyme. Specifically, recent findings demonstrated that DCI influences the enzyme gene expression, thus reducing the conversion of androgens into estrogens. Expert opinion Available evidence suggests that the effects of DCI administration may be similar to those of aromatase inhibitors, but without causing hypo-estrogenic states. Therefore, DCI treatments should be evaluated for either estrogen-dependent gynecological conditions or low testosterone states in male subjects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available