Related references
Note: Only part of the references are listed.Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
Eunhee Choi et al.
NATURE COMMUNICATIONS (2019)
Gender Differences in Clinical Predictors of Nonalcoholic Steatohepatitis in Type 2 Diabetes
Shashi Panicker et al.
DIABETES (2019)
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex
Emiko Uchikawa et al.
ELIFE (2019)
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
Mingxia Zhao et al.
ACTA PHARMACEUTICA SINICA B (2019)
Comprehensive Analysis of ERK1/2 Substrates for Potential Combination Immunotherapies
Lei Yang et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2019)
SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
Tamer A. Ahmed et al.
CELL REPORTS (2019)
Biochemical and cellular properties of insulin receptor signalling
Rebecca A. Haeusler et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Mechanisms of clathrin-mediated endocytosis
Marko Kaksonen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Yosuke Yoneyama et al.
ELIFE (2018)
Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis
Giovanna Scapin et al.
NATURE (2018)
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1-and RAS-driven cancers
Robert J. Nichols et al.
NATURE CELL BIOLOGY (2018)
MECHANISMS OF INSULIN ACTION AND INSULIN RESISTANCE
Max C. Petersen et al.
PHYSIOLOGICAL REVIEWS (2018)
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
Carmine Fedele et al.
CANCER DISCOVERY (2018)
The signalling conformation of the insulin receptor ectodomain
Felix Weis et al.
NATURE COMMUNICATIONS (2018)
Spindle Checkpoint Regulators in Insulin Signaling
Eunhee Choi et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)
A compendium of ERK targets
Evrim B. Uenal et al.
FEBS LETTERS (2017)
Insulin action and resistance in obesity and type 2 diabetes
Michael P. Czech
NATURE MEDICINE (2017)
A Unified Pathoohysiolocical Construct of Diaoetes and its Complications
Stanley S. Schwartz et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo
ZhongQian Hu et al.
ONCOTARGETS AND THERAPY (2017)
Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes
Kei-ichi Ozaki et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)
Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis
Eunhee Choi et al.
CELL (2016)
The Time Is Right for a New Classification System for Diabetes: Rationale and Implications of the β-Cell-Centric Classification Schema
Stanley S. Schwartz et al.
DIABETES CARE (2016)
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Ying-Nan P. Chen et al.
NATURE (2016)
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
Andrea Musacchio
CURRENT BIOLOGY (2015)
EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR
Christopher M. Furcht et al.
SCIENCE SIGNALING (2015)
EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR
Christopher M. Furcht et al.
SCIENCE SIGNALING (2015)
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
Daisuke Izawa et al.
NATURE (2015)
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
Alexander S. Banks et al.
NATURE (2015)
Signalling dynamics in the spindle checkpoint response
Nitobe London et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity
Mylene Tajan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Insulin Receptor Signaling in Normal and Insulin-Resistant States
Jeremie Boucher et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Sequencing analysis of insulin receptor defects and detection of two novel mutations in INSR gene
O. Ardon et al.
MOLECULAR GENETICS AND METABOLISM REPORTS (2014)
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Emily A. Foley et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Tracking spindle checkpoint signals from kinetochores to APC/C
Luying Jia et al.
TRENDS IN BIOCHEMICAL SCIENCES (2013)
Cargo Recognition in Clathrin-Mediated Endocytosis
Linton M. Traub et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
K. D. Copps et al.
DIABETOLOGIA (2012)
Chromosomal instability and aneuploidy in cancer: from yeast to man
Sarah J. Pfau et al.
EMBO REPORTS (2012)
Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice
Naoto Nagata et al.
ENDOCRINOLOGY (2012)
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
Nicola Aceto et al.
NATURE MEDICINE (2012)
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
J. Jager et al.
DIABETOLOGIA (2011)
Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31comet
Luying Jia et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment
Robert S. Hagan et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
MAPK signalling in cellular metabolism: stress or wellness?
Helmuth Gehart et al.
EMBO REPORTS (2010)
Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2
Kosuke Matsuo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling
Thomas Edouard et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
Eunhee Choi et al.
EMBO JOURNAL (2009)
Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70(S6K) activities in the liver of obese Zucker rats
Yanbin Zheng et al.
JOURNAL OF ENDOCRINOLOGY (2009)
Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death
Frederic Princen et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Andrew J. Holland et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Insulin Resistance and Hyperinsulinemia Is hyperinsulinemia the cart or the horse?
Michael H. Shanik et al.
DIABETES CARE (2008)
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Darren J. Baker et al.
NATURE CELL BIOLOGY (2008)
Protein Metamorphosis: The Two-State Behavior of Mad2
Xuelian Luo et al.
STRUCTURE (2008)
MAD contortions: conformational dimerization boosts spindle checkpoint signaling
Marina Mapelli et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
p31comet blocks Mad2 activation through structural mimicry
Maojun Yang et al.
CELL (2007)
Cdc20: A WD40 activator for a cell cycle degradation machine
Hongtao Yu
MOLECULAR CELL (2007)
The anaphase promoting complex/cyclosome: a machine designed to destroy
Jan-Michael Peters
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia
RZ Xu et al.
BLOOD (2005)
Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes
I Hers et al.
BIOCHEMICAL JOURNAL (2005)
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
EA Bard-Chapeau et al.
NATURE MEDICINE (2005)
Germ-line and somatic PTPN11 mutations in human disease
M Tartaglia et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS (2005)
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
F Bost et al.
DIABETES (2005)
Conformation-specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint
GH Xia et al.
EMBO JOURNAL (2004)
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
EE Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding protein-2 at serine residues 432 and 455 in vivo
J Kotzka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
Y Yao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
MK Saba-El-Leil et al.
EMBO REPORTS (2003)
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
K Bouzakri et al.
DIABETES (2003)
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
M Tartaglia et al.
NATURE GENETICS (2003)
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
BG Neel et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes - Potential role of p38 in the downregulation of GLUT4 expression
CJ Carlson et al.
DIABETES (2003)
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
SE Kahn
DIABETOLOGIA (2003)
Essential role for ERK2 mitogen-activated protein kinase in placental development
N Hatano et al.
GENES TO CELLS (2003)
Identification of a MAD2-binding protein, CMT2, and its role in mitosis
T Habu et al.
EMBO JOURNAL (2002)
Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2
SQ Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
V Sudakin et al.
JOURNAL OF CELL BIOLOGY (2001)
MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
G Roth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)