A decade of radiomics research: are images really data or just patterns in the noise?

Key Points center dot Although radiomics is potentially a promising approach to analyze medical image data, many pitfalls need to be considered to avoid a reproducibility crisis.center dot There is a translation gap in radiomics research, with many studies being published but so far little to no translation into clinical practice.center dot Going forward, more studies with higher levels of evidence are needed, ideally also focusing on prospective studies with relevant clinical impact.

Automated summary

Although radiomics shows promise in analyzing medical image data, there are pitfalls to avoid for reproducibility. There is a gap in translating radiomics research into clinical practice, and more high-evidence studies focusing on prospective research with clinical impact are needed going forward.