Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 879, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2020.173134
Keywords
METTL3; Cervical cancer; RAB2B; Proliferation
Categories
Funding
- National Natural Science Foundation of China [81973343, 81673454]
- Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]
- Fundamental Research Funds for the Central Universities (Sun Yat-sen University) [16ykpy09]
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Cervical cancer is one of the leading causes of cancer death in women worldwide. While molecular mechanisms of initiation and cervical carcinogenesis are not well studied. Our data showed that the expression of Methyltransferase-like 3 (METTL3) was upregulated in cervical tumor tissues as compared with normal tissues. Its expression was associated with poor prognosis of cervical cancer. Knockdown of METTL3 can suppress the proliferation of cervical cancer cells. The expression of METTL3 was significantly correlated with the expression of RAB2B, one member of RAS oncogene family. Over expression of RAB2B can significantly attenuate shMETTL3-suppressed cell proliferation. Mechanistically, METTL3 can increase the mRNA stability of RAB2B via an IGF2BP3-dependent manner. Collectively, METTL3 can trigger growth of cervical cancer cells via upregulation of RAB2B. It indicated that METTL3 might be a potential target for cervical cancer therapy.
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