Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 151, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2020.105372
Keywords
Emulgel; Curcumin; Tissue-engineering; Oral squamous cell carcinoma; Ex vivo permeation; Mucoadhesion
Categories
Funding
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/Coordination for the Improvement of Higher Education of Brazil) [88881.188732/2018-01-PDSE, 001]
- CNPq (Conselho Nacional de DesenvolvimentoCientifico e Tecnologico/National Counsel of Technological and Scientific Development of Brazil) [307442/2017-9]
- FINEP (Financiadora de Estudos e Projetos/Financier of Studies and Projects of Brazil)
- State University of Maringa
- University of Sheffield
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Current oral squamous cell carcinoma chemotherapies demonstrate off -target toxicity, which could be reduced by local delivery. Curcumin acts via many cellular targets to give anti -cancer properties; however the bioa- vailability is hindered by its physicochemical characteristics. The incorporation of curcumin into emulgel sys- tems could be a promising approach for its solubilization and delivery. The aim of this work was to develop emulgel systems containing curcumin for the treatment of oral cancer. The emulgels containing curcumin were prepared with poloxamer 407, acrylic acid derivatives, oil phase (sesame oil or isopropyl myristate). The more stable system was evaluated for mechanical and rheological properties, as well as, the in vitro drug release profile, permeation and cytotoxic potential to oral mucosa models. The flow -throw system evidenced that the formulations could keep 5 min over porcine oral mucosa. Emulgel showed pseudoplastic behavior and a gelation temperature of 33 degrees C, which ensure their higher consistency. In addition, 70% of the incorporated curcumin was released within 24 h in an in vitro drug release study and could permeate porcine oral mucosa. Monolayers cultures and tissue -engineered models showed the selectivity of the drug and systems for tumor cells. The physicochemical properties, subsequent release and permeation of curcumin to selectivity kill cancer cells could be improved by the incorporation into emulgel systems.
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