Journal
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Volume 39, Issue 6, Pages 1059-1061Publisher
SPRINGER
DOI: 10.1007/s10096-020-03913-9
Keywords
SARS-CoV2; Covid-19; RT-PCR; Co-culture; Viral load; Correlation
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Funding
- French Government under the Investissements d'avenir (Investments for the Future) program [10-IAHU-03]
- Region Provence-Alpes-Cote d'Azur
- European funding FEDER PRIMI
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In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients.
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