Epidemiological study ofTrichosporon asahiiinfections over the past 23 years

Trichosporon is a yeast-like basidiomycete, a conditional pathogenic fungus that is rare in the clinic but often causes fatal infections in immunocompromised individuals.Trichosporon asahiiis the most common pathogenic fungus in this genus and the occurrence of infections has dramatically increased in recent years. Here, we report a systematic literature review detailing 140 cases ofT. asahiiinfection reported during the past 23 years. Statistical analysis shows thatT. asahiiinfections were most frequently reported within immunodeficient or immunocompromised patients commonly with blood diseases. Antibiotic use, invasive medical equipment and chemotherapy were the leading risk factors for acquiring infection.In vitrosusceptibility, clinical information and prognosis analysis showed that voriconazole is the primary drug of choice in the treatment ofT. asahiiinfection. Combination treatment with voriconazole and amphotericin B did not show superiority over either drug alone. Finally, we found that the types of infections prevalent in China are significantly different from those in other countries. These results provide detailed information and relevant clinical treatment strategies for the diagnosis and treatment ofT. asahiiinfection.