Swietenine extracted fromSwieteniarelieves myocardial hypertrophy induced by isoprenaline in mice

As a traditional plant medicine in tropical areas,Swietenia macrophyllaseeds are usually applied for some chronic diseases, including hypertension, diabetes, and so on. Few studies have been carried out to identify the effective elements in seed extract and their indications. In this study, we first investigated the functions of the swietenine, an extract fromS. macrophyllaseeds, using a model of myocardial hypertrophy induced by isoprenaline (ISO). At cellular level, H9c2 cell hypertrophy was also established through the treatment with ISO. The cardiac pathological remodeling was evaluated by echocardiography and histological analysis. Western blot and RT-qPCR were used to detect the expression of possible hypertrophy-promoting genes. Here, our results indicated that swietenine remarkably attenuated ISO-induced myocardial hypertrophy in vivo and in vitro. Moreover, Akt phosphorylation, ANP and BNP mRNA expression were efficiently decreased.Based on these findings, we concluded that swietenine might be a promising anti-hypertrophic agent against cardiac hypertrophy.