Journal
ENDOCRINOLOGY
Volume 161, Issue 9, Pages -Publisher
ENDOCRINE SOC
DOI: 10.1210/endocr/bqaa108
Keywords
renin-angiotensin system; ACE2; TMPRSS-2; SARS-CoV-2; COVID-19; diabetes
Categories
Funding
- American Diabetes Association [1-19-IBS-291]
- National Institutes of Health [HL150592, DK107444, DK074970]
- Department of Veterans Affairs Merit review awards [BX004294, BX003725]
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The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.
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