Journal
CIRCULATION-CARDIOVASCULAR GENETICS
Volume 9, Issue 3, Pages 291-313Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HCG.0000000000000030
Keywords
AHA Scientific Statements; diet; metagenomics; microbiota; nutrigenetics; nutrigenomics; nutritional status
Funding
- NHLBI NIH HHS [R01 HL128572] Funding Source: Medline
- NIDDK NIH HHS [P30 DK056350] Funding Source: Medline
- NIEHS NIH HHS [K22 ES023849] Funding Source: Medline
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Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple omic measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.
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