Journal
CIRCULATION RESEARCH
Volume 118, Issue 3, Pages 496-514Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.115.306573
Keywords
myocarditis; heart diseases; communicable diseases; virus diseases; cardiovascular infections
Funding
- Canadian Institutes of Health Research
- Heart AMP
- Stroke Foundation of Canada
- Canadian Institutes of Health Research
- Heart AMP
- Stroke Foundation of Canada
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Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.
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