Journal
CIRCULATION RESEARCH
Volume 118, Issue 1, Pages 95-107Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.115.305373
Keywords
fibroblast growth factor; heart diseases; myocardial infarction; regeneration; stem cells
Funding
- National Heart, Lung, and Blood Institute [RO1 HL81744, HL72010, HL73219]
- Edna and Fred L. Mandel Jr. Foundation
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In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
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