Journal
CIRCULATION RESEARCH
Volume 118, Issue 8, Pages 1254-1263Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.115.307347
Keywords
heart failure; myocardial infarction; meta-analysis; outcome measures; stem cells
Funding
- NHLBI NIH HHS [UM1 HL087365, UM1 HL087318, 5 UM1 HL087318-01] Funding Source: Medline
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In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfalls of different types of meta-analyses are reviewed here. Each meta-analysis approach has a place when pivotal clinical trials are lacking and sheds light on the magnitude of the treatment in a complex healthcare field.
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