Journal
DEVELOPMENTAL PSYCHOBIOLOGY
Volume 63, Issue 1, Pages 54-64Publisher
WILEY
DOI: 10.1002/dev.21986
Keywords
adaptive flexibility; FMP Y-maze; moderate-stress; novel tank; resilience; shoal test
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
- Science Faculty Studentship from the University of Portsmouth
- BBSRC [BB/M007863/1]
- Leverhulme grant [RPG-2016-143]
- Human Frontiers grant [HFSP-RGP0008/2017]
- European Union's Horizon 2020 research and innovation programme (Marie Sklodowska-Curie Action) [750200]
- Marie Curie Actions (MSCA) [750200] Funding Source: Marie Curie Actions (MSCA)
- BBSRC [BB/M007863/1] Funding Source: UKRI
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Research shows that moderate early life stress affects adult zebrafish behavior by increasing working memory, but has no significant impact on shoaling cohesion, locomotion, or anxiety behavior.
Early life stress (ELS) is defined as a short or chronic period of trauma, environmental or social deprivation, which can affect different neurochemical and behavioral patterns during adulthood. Zebrafish (Danio rerio) have been widely used as a model system to understand human neurodevelopmental disorders and display translationally relevant behavioral and stress-regulating systems. In this study, we aimed to investigate the effects of moderate ELS by exposing young animals (6-weeks postfertilization), for 3 consecutive days, to three stressors, and analyzing the impact of this on adult zebrafish behavior (16-week postfertilization). The ELS impact in adults was assessed through analysis of performance on tests of unconditioned memory (free movement pattern Y-maze test), exploratory and anxiety-related task (novel tank diving test), and social cohesion (shoaling test). Here, we show for the first time that moderate ELS increases the number of alternations in turn-direction compared to repetitions in the unconditioned Y-maze task, suggesting increased working memory, but has no effect on shoal cohesion, locomotor profile, or anxiety-like behavior. Overall, our data suggest that moderate ELS may be linked to adaptive flexibility which contributes to build resilience in adult zebrafish by improving working memory performance.
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