Journal
CIRCULATION RESEARCH
Volume 118, Issue 3, Pages 439-453Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.115.306305
Keywords
biostatistics; survival analysis; research; regression analysis; research design
Funding
- National Heart Lung and Blood Institute [UM1 HL087318]
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Rationale: Biostatistics continues to play an essential role in contemporary cardiovascular investigations, but successful implementation of biostatistical methods can be complex. Objective: To present the rationale behind statistical applications and to review useful tools for cardiology research. Methods and Results: Prospective declaration of the research question, clear methodology, and study execution that adheres to the protocol together and serve as the critical foundation of a research endeavor. Both parametric and distribution-free measures of central tendency and dispersion are presented. T testing, ANOVA, and regression analyses are reviewed. Survival analysis, logistic regression, and interim monitoring are also discussed. Finally, common weaknesses in statistical analyses are considered. Conclusions: Biostatistics can be productively applied to cardiovascular research if investigators (1) develop and rely on a well-written protocol and analysis plan, (2) consult with a biostatistician when necessary, and (3) write results clearly, differentiating confirmatory from exploratory findings.
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