Journal
DEVELOPMENTAL CELL
Volume 54, Issue 1, Pages 7-20Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2020.06.008
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Funding
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Heart Lung and Blood Institute (NHLBI)
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003164] Funding Source: NIH RePORTER
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Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton. Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin isoforms and post-translational modifications, a tubulin code,'' which is thought to support the diverse morphology and dynamics of microtubule arrays across various cell types, cell cycle, and developmental stages. We give a brief historical overview of research into tubulin diversity and highlight recent progress toward uncovering the mechanistic underpinnings of the tubulin code. As a large number of essential pathways converge upon the microtubule cytoskeleton, understanding how cells utilize tubulin diversity is crucial to understanding cellular physiology and disease.
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