Journal
DEVELOPMENT
Volume 147, Issue 11, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.175786
Keywords
Aging; CircRNAs; Mitochondria; Transposable elements
Categories
Funding
- USC
- National Institute on Aging [T32 AG052374, R00 AG049934, R21 AG063739]
- National Science Foundation [DGE-1842487]
- Rose Hills Foundation
- NAVIGAGE Foundation
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Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging classes of molecules with promise as aging modulators include transposable elements, circRNAs and the mitochondria! transcriptome. Analytical complexity means that these molecules are often overlooked, even though they exhibit strong associations with aging and, in some cases, may directly contribute to its progress. Here, we review the links between these novel factors and age-related phenotypes, and we suggest tools that can be easily incorporated into existing pipelines to better understand the aging process.
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