Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 55, Issue -, Pages 58-69Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2020.07.011
Keywords
Pancreatic cancer; Therapeutic resistance; Heat shock protein; Protein methylation
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Funding
- Guangzhou Municipality Bureau of Science and Technology, Guangzhou, China
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Pancreatic cancer is a lethal disease with limited treatment options for cure. A high degree of intrinsic and acquired therapeutic resistance may result from cellular alterations in genes and proteins involved in drug transportation and metabolism, or from the influences of cancer microenvironment. Mechanistic basis for therapeutic resistance remains unclear and should profoundly impact our ability to understand pancreatic cancer pathogenesis and its effective clinical management. Recent evidences have indicated the importance of epigenetic changes in pancreatic cancer, including posttranslational modifications of proteins. We will review new knowledge on protein arginine methylation and its consequential contribution to therapeutic resistance of pancreatic cancer, underlying molecular mechanism, and clinical application of potential strategies of its reversal.
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