Journal
CYTOKINE & GROWTH FACTOR REVIEWS
Volume 54, Issue -, Pages 62-75Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2020.06.001
Keywords
COVID-19; SARS-CoV-2; Chemokines; Growth factors; Cytokine storm
Categories
Funding
- Junta de Andalucia [BIO277]
- Department of Nursing of the University of Granada
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COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
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