Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 26, Issue 26, Pages 3085-3095Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666200610183048
Keywords
STING; innate immune response; type I interferon; cGAMP; cGAS; anti-tumor immunity
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Funding
- Natural Scientific Foundation of Heilongjiang Province
- Scientific Research Project of Health and Family Planning Commission of Heilongjiang Province [2016-170]
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Stimulator of interferon genes is an important innate immune signaling molecule in the body and is involved in the innate immune signal transduction pathway induced by pathogen-associated molecular patterns or damage-associated molecular patterns. Stimulator of interferon genes promotes the production of type I interferon and thus plays an important role in the innate immune response to infection. In addition, according to a recent study, the stimulator of interferon genes pathway also contributes to anti-inflammatory and anti-tumor reactions. In this paper, current researches on the Stimulator of interferon genes signaling pathway and its relationship with tumor immunity are reviewed. Meanwhile, a series of critical problems to be addressed in subsequent studies are discussed as well.
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