Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 26, Issue 33, Pages 4032-4047Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612826666200603124418
Keywords
Polyphenols; catechin; therapeutic uses; drug delivery systems; pathologic processes; oral health
Categories
Funding
- CNPq
- FAPEMIG
- CAPES
- FUNEPU
- NIDR
- INCT-TeraNano, Brazil
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Research regarding polyphenols has gained pmminence over the years because of their potential as pharmacological nutrients. Most polyphenols are fiavanols, commonly known as catechins, which are present in high amounts in green tea. Catechins are pmmising candidates in the field of biomedicine. The health benefits of catechins, notably their antioxidant effects, are related to their chemical structure and the total number of hydroxyl groups. In addition, catechins possess strong activities against several pathogens, including bacteria, viruses, parasites, and fungi. One major limitation of these compounds is low bioavailability. Catechins are poorly absorbed by intestinal barriers. Some protective mechanisms may be required to maintain or even increase the stability and bioavailability of these molecules within living organisms. Moreover, novel delivery systems, such as scaffolds, fibers, sponges, and capsules, have been proposed. This review focuses on the unique structures and bioactive properties of catechins and their role in inflammatory responses as well as provides a perspective on their use in future human health applications.
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