Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 62, Issue -, Pages 102-111Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.12.002
Keywords
-
Categories
Funding
- N.I.H. [P41-GM103311]
- Independent Research Fund Denmark [7025-00083B]
- [P41GM103694]
Ask authors/readers for more resources
Post-translational modifications (PTMs) drive the diversity of the proteome and broadly regulate protein function. Interplay between different types of PTMs further enables tight and dynamic finetuning of molecular functions. O-Glycosylation on serine, threonine, and tyrosine residues is a major PTM with diverse roles in development, differentiation, pathogenesis, and proteolytic processing. Other examples of cross-talk between PTMs also exist, such as PSGL-1, where the combined presence of N-terminal sulfotyrosines and O-glycans is pivotal for selectin binding. A handful of other related examples of O-glycans and sulfotyrosine co-localization has been described but it is not yet recognized as a general regulatory phenomenon. In this review, we highlight the emerging global pattern of co-localization of cell-surface and extracellular sulfotyrosines with O-glycans, which we term 'multi-motif' interactions, from a wide range of protein classes. We also discuss the barriers, and existing and future tools needed to dissect the biological impact and biomedical potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available