Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 64, Issue -, Pages 1-8Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2019.12.005
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Funding
- National Institutes of Health [AI114495, AI145932]
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In order to get recognized by CD8 T cells, most cells present peptides from endogenously expressed self or foreign proteins on MHC class I molecules. However, specialized antigen-presenting cells, such as DCs and macrophages, can present exogenous antigen on MHC-I in a process called cross-presentation. This pathway plays key roles in antimicrobial and antitumor immunity, and also immune tolerance. Recent advances have broadened our understanding of the underlying mechanisms of cross-presentation. Here, we review some of these recent advances, including the distinct pathways that result in the cross-priming of CD8 T cells and the source of the class I molecules presenting exogenous peptides.
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