Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 57, Issue -, Pages 135-154Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.05.009
Keywords
Chemical probes; Drug discovery; Multitargeting agents; Epigenetics
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Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.
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