Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 57, Issue -, Pages 114-121Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.06.008
Keywords
Ultrasonography; Photoacoustic imaging; Ultrasound bubbles; Acoustogenic probes; Ultrasound-responsive materials; Tumor microenvironment; Drug delivery; Molecular imaging
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Funding
- Alfred P. Sloan Foundation
- National Institutes of Health [R35GM133581]
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Acoustic-based imaging modalities (e.g. ultrasonography and photoacoustic imaging) have emerged as powerful approaches to noninvasively visualize the interior of the body due to their biocompatibility and the ease of sound transmission in tissue. These technologies have recently been augmented with an array of chemical tools that enable the study and modulation of the tumor microenvironment at the molecular level. In addition, the application of ultrasound and ultrasound-responsive materials has been used for drug delivery with high spatiotemporal control. In this review, we highlight recent advances (in the last 2-3 years) in acoustic-based chemical tools and technologies suitable for furthering our understanding of molecular events in complex tumor microenvironments.
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