Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 56, Issue -, Pages 91-97Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.03.003
Keywords
Chemical probes; Target identification; Chemogenomics libraries; Phenotypic screens; Molecular glues; Chemical proteomics; CETSA; LiP
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Chemical probes are essential tools used to study and modulate biological systems. Here, we describe some of the recent scientific advancement in the field of chemical biology, as well as how the advent of new technologies is redefining the criteria of 'good' chemical probes and influencing the discovery of valuable drug leads. In this review, we report selected examples of the usage of linkered and linker-free chemical probes for target identification, biological discovery, and general mechanistic understanding. We also discuss the promises of chemogenomics libraries in phenotypic screens, as well as the limitation of their usage to identify the modulation of new targets and biology.
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