Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 63, Issue -, Pages 41-47Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2019.11.015
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Funding
- National Science Foundation through CMMI Award [1727189]
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Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attention in recent years with the advent of synthetic biology, mostly as a convenient property to perform bottom-up design of complex systems. A number of studies have appeared, which fundamentally challenge modularity as a property of engineered biological circuits. Here, we summarize some of these studies and potential engineering solutions that have been proposed to enable modular composition of biological circuits.
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