4.6 Review

Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections

Related references

Note: Only part of the references are listed.
Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

Review Oncology

Drug repurposing for breast cancer therapy: Old weapon for new battle

Sadhna Aggarwal et al.

Summary: Drug repurposing is a novel approach for drug development that involves repositioning clinically approved non-cancer drugs with known targets to newer indications, resulting in faster, more effective, cheaper, and safer drugs with reduced known side effects. Several drugs have been successfully repositioned for breast cancer treatment, especially for the most aggressive triple negative breast cancer. Serendipity plays a key role in drug development, and challenges associated with drug repurposing are also discussed in the literature.

SEMINARS IN CANCER BIOLOGY (2021)

Review Oncology

Current state and future perspective of drug repurposing in malignant glioma

Markus David Siegelin et al.

Summary: Malignant gliomas are difficult to treat due to their invasive nature and resistance to adjuvant therapies. Drug repurposing is a promising approach to discover new treatments for these tumors, as it can accelerate the process and utilize existing drugs with known safety profiles.

SEMINARS IN CANCER BIOLOGY (2021)

Article Oncology

Repurposing drugs in oncology: From candidate selection to clinical adoption

Pan Pantziarka et al.

Summary: Drug repurposing is a strategy to develop novel cancer treatments by reusing existing medicines developed in other disease areas. Key issues include candidate drug selection, clinical trial development, drug licensing/approval, and clinical adoption.

SEMINARS IN CANCER BIOLOGY (2021)

Review Oncology

Drug repurposing for cancer therapy, easier said than done

Aurora Gonzalez-Fierro et al.

Summary: Drug repurposing for cancer therapy is a hot topic of research with potential advantages of being faster, safer, easier, and cheaper. However, economic barriers are the main challenge in clinical development, hindering the acceptance of repositioned drugs as standard therapy at low cost.

SEMINARS IN CANCER BIOLOGY (2021)

Review Oncology

Turning liabilities into opportunities: Off-target based drug repurposing in cancer

Vinayak Palve et al.

Summary: Drug repurposing is an attractive complementary approach to traditional drug discovery, especially with the increasing demand for new drugs tailored to smaller patient populations. Most targeted drugs are not singularly specific, and some unintended drug off-target effects can lead to beneficial anticancer targets, contributing to novel and promising precision medicine approaches.

SEMINARS IN CANCER BIOLOGY (2021)

Article Oncology

Old drugs, new uses: Drug repurposing in hematological malignancies

Vijay P. Kale et al.

Summary: The discovery and development of novel anti-cancer drugs is costly and time-consuming. Utilizing drugs developed for non-cancer indications for hematological malignancies can significantly reduce costs and development time, as they have already undergone preclinical and clinical development. Repurposing such drugs can be an efficient strategy for treating cancer.

SEMINARS IN CANCER BIOLOGY (2021)

Review Biotechnology & Applied Microbiology

Drug databases and their contributions to drug repurposing

Yosef Masoudi-Sobhanzadeh et al.

GENOMICS (2020)

Article Chemistry, Medicinal

Drugs for the Treatment of Zika Virus Infection

Jean A. Bernatchez et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Pharmacology & Pharmacy

In silico drug repurposing for the identification of potential candidate molecules against arboviruses infection

Diana Montes-Grajales et al.

ANTIVIRAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Ribavirin does not potentiate favipiravir antiviral activity against Ebola virus in non-human primates

Vincent Madelain et al.

ANTIVIRAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

Cephalotaxine inhibits Zika infection by impeding viral replication and stability

Zheng-Zong Lai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities

Xiaohong Du et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Pharmacology & Pharmacy

Repurposing of drugs approved for cardiovascular diseases: Opportunity or mirage?

Paolo Gelosa et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Drug repurposing in cardiovascular diseases: Opportunity or hopeless dream?

Paolo Gelosa et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Next-generation drug repurposing using human genetics and network biology

Serguei Nabirotchkin et al.

CURRENT OPINION IN PHARMACOLOGY (2020)

Review Critical Care Medicine

Treatment of Ebola-related critical illness

Peter Kiiza et al.

INTENSIVE CARE MEDICINE (2020)

Editorial Material Infectious Diseases

Chloroquine for the 2019 novel coronavirus SARS-CoV-2

Philippe Colson et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Infectious Diseases

Arguments in favour of remdesivir for treating SARS-CoV-2 infections

Wen-Chien Ko et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Review Infectious Diseases

Discovery and development of safe-in-man broad-spectrum antiviral agents

Petter I. Andersen et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Chemistry, Medicinal

Identification of Zika Virus NS2B-NS3 Protease Inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches

Felipe R. S. Santos et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

Article Medicine, Research & Experimental

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Abdo A. Elfiky

LIFE SCIENCES (2020)

Editorial Material Biotechnology & Applied Microbiology

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Guangdi Li et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Pharmacology & Pharmacy

Favipiravir, an anti-influenza drug against life-threatening RNA virus infections

Kimiyasu Shiraki et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Editorial Material Medicine, General & Internal

Clinical trials in an Ebola outbreak seek to find an evidence-based cure

Laura K. McMullan

EBIOMEDICINE (2020)

Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

Review Medicine, General & Internal

New Drugs Approved in 2019

Alex M. Ebied et al.

AMERICAN JOURNAL OF MEDICINE (2020)

Article Pharmacology & Pharmacy

Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses

V. M. Quintana et al.

ANTIVIRAL RESEARCH (2020)

Review Pharmacology & Pharmacy

Of chloroquine and COVID-19

Franck Touret et al.

ANTIVIRAL RESEARCH (2020)

Article Chemistry, Medicinal

Repurposed drug candidates for antituberculosis therapy

Qi An et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Infectious Diseases

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Christian A. Devaux et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Infectious Diseases

Teicoplanin: an alternative drug for the treatment of COVID-19?

Sophie Alexandra Baron et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Article Immunology

Lopinavir/ritonavir did not shorten the duration of SARS CoV-2 shedding in patients with mild pneumonia in Taiwan

Chien-Yu Cheng et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

Article Public, Environmental & Occupational Health

Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence

Yu-chen Cao et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Article Mathematical & Computational Biology

Deep Learning Based Drug Screening for Novel Coronavirus 2019-nCov

Haiping Zhang et al.

INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2020)

Article Engineering, Multidisciplinary

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

Qingxian Cai et al.

ENGINEERING (2020)

Article Medicine, General & Internal

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

Joshua Geleris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Editorial Material Immunology

It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19)

Lidia Morawska et al.

CLINICAL INFECTIOUS DISEASES (2020)

Article Pharmacology & Pharmacy

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Leon Caly et al.

ANTIVIRAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Ka-Tim Choy et al.

ANTIVIRAL RESEARCH (2020)

Review Critical Care Medicine

A systematic review on the ef ficacy and safety of chloroquine for the treatment of COVID-19

Andrea Cortegiani et al.

JOURNAL OF CRITICAL CARE (2020)

Review Public, Environmental & Occupational Health

Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses

E. Susan Amirian et al.

ONE HEALTH (2020)

Review Engineering, Biomedical

Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine

Ajay Vikram Singh et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Editorial Material Public, Environmental & Occupational Health

COVID-19 and the rush for self-medication and self-dosing with ivermectin: A word of caution

Marcelo Beltrao Molento

ONE HEALTH (2020)

Article Multidisciplinary Sciences

Coumarin: An emerging antiviral agent

Shruti Mishra et al.

HELIYON (2020)

Article Pharmacology & Pharmacy

Inhibition of dengue virus by curcuminoids

Anuradha Balasubramanian et al.

ANTIVIRAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Drug repurposing of N-acetyl cysteine as antiviral against dengue virus infection

Gopinathan Pillai Sreekanth et al.

ANTIVIRAL RESEARCH (2019)

Review Medicine, Research & Experimental

An update on Drug Repurposing: Re-written saga of the drug's fate

Hema G. N. S. Sree et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Pharmacology & Pharmacy

Repurposing host-based therapeutics to control coronavirus and influenza virus

Cui-Cui Li et al.

DRUG DISCOVERY TODAY (2019)

Article Virology

Antimalarial drugs and their metabolites are potent Zika virus inhibitors

Yingshan Han et al.

JOURNAL OF MEDICAL VIROLOGY (2019)

Article Nursing

Zika: An Unfolding Story

Marilou Shreve et al.

JNP-JOURNAL FOR NURSE PRACTITIONERS (2019)

Review Infectious Diseases

Anti-Ebola therapy for patients with Ebola virus disease: a systematic review

James S. Lee et al.

BMC INFECTIOUS DISEASES (2019)

Article Virology

Drug repurposing for new, efficient, broad spectrum antivirals

Moises Garcia-Serradilla et al.

VIRUS RESEARCH (2019)

Article Virology

Strategies for Zika drug discovery

Jing Zou et al.

CURRENT OPINION IN VIROLOGY (2019)

Article Virology

Status of antiviral therapeutics against rabies virus and related emerging lyssaviruses

Venice Du Pont et al.

CURRENT OPINION IN VIROLOGY (2019)

Article Virology

Current status of small molecule drug development for Ebola virus and other filoviruses

Megan R. Edwards et al.

CURRENT OPINION IN VIROLOGY (2019)

Article Pharmacology & Pharmacy

Antiviral activity of pinocembrin against Zika virus replication

Jia Le Lee et al.

ANTIVIRAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses

Edeildo Ferreira da Silva-Junior et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Review Pharmacology & Pharmacy

Drug repurposing: a promising tool to accelerate the drug discovery process

Vineela Parvathaneni et al.

DRUG DISCOVERY TODAY (2019)

Article Virology

Emerging arboviruses of medical importance in the Mediterranean region

Anna Papa

JOURNAL OF CLINICAL VIROLOGY (2019)

Article Biochemistry & Molecular Biology

Carnosine exhibits significant antiviral activity against Dengue and Zika virus

Hussin A. Rothan et al.

JOURNAL OF PEPTIDE SCIENCE (2019)

Editorial Material Clinical Neurology

An extremely aggressive case of Marburg's disease treated with high dose cyclophosphamide. A case report

Jose Avila-Ornelas et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Review Pharmacology & Pharmacy

Deep learning in drug discovery: opportunities, challenges and future prospects

Antonio Lavecchia

DRUG DISCOVERY TODAY (2019)

Review Pharmacology & Pharmacy

Insights into Computational Drug Repurposing for Neurodegenerative Disease

Manish D. Paranjpe et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Pharmacology & Pharmacy

High-throughput screening for negative-stranded hemorrhagic fever viruses using reverse genetics

Lisa Wendt et al.

ANTIVIRAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Antiviral activity of ST081006 against the dengue virus

Jing Kai Lee et al.

ANTIVIRAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Small molecule grp94 inhibitors block dengue and Zika virus replication

Hussin A. Rothan et al.

ANTIVIRAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Improving therapy of severe infections through drug repurposing of synergistic combinations

Yu-Shan Cheng et al.

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Chemistry, Medicinal

De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus

Emilse S. Leal et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work

Rajesh Kumar et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Pharmacology & Pharmacy

Micro-nanorobots: important considerations when developing novel drug delivery platforms

Ajay Vikram Singh et al.

Expert Opinion on Drug Delivery (2019)

Article Pharmacology & Pharmacy

Tomatidine, a novel antiviral compound towards dengue virus

Mayra Diosa-Toro et al.

ANTIVIRAL RESEARCH (2019)

Article Biochemistry & Molecular Biology

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

Christopher J. Penny et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Article Pharmacology & Pharmacy

Antiviral effects of simeprevir on multiple viruses

Zheng Li et al.

ANTIVIRAL RESEARCH (2019)

Article Pharmacology & Pharmacy

Antiviral activity of the FDA-approved drug candesartan cilexetil against Zika virus infection

Marcus Wing Choy Loe et al.

ANTIVIRAL RESEARCH (2019)

Article Dermatology

Going Viral 2019 Zika, Chikungunya, and Dengue

Jose Dario Martinez et al.

DERMATOLOGIC CLINICS (2019)

Review Pharmacology & Pharmacy

The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions

Prasanthi Polamreddy et al.

DRUG DISCOVERY TODAY (2019)

Review Virology

Perspectives towards antiviral drug discovery against Ebola virus

Muhammad Usman Mirza et al.

JOURNAL OF MEDICAL VIROLOGY (2019)

Article Chemistry, Medicinal

Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection

Olusola Olafuyi et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Article Biotechnology & Applied Microbiology

Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine

Ilker Kudret Sariyer et al.

MOLECULAR THERAPY (2019)

Editorial Material Biotechnology & Applied Microbiology

Repurposing an HIV Drug for Zika Virus Therapy

Xuping Xie et al.

MOLECULAR THERAPY (2019)

Review Chemistry, Medicinal

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Elena K. Schneider-Futschik et al.

ACS INFECTIOUS DISEASES (2019)

Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Pharmacology & Pharmacy

Efficacy of favipiravir (T-705) in nonhuman primates infected with Ebola virus or Marburg virus

Sandra L. Bixler et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

Szu-Yuan Pu et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease

Yong Wah Tan et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

Min-Han Lin et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Repurposing potential of 1st generation H-1-specific antihistamines as anti-filovirus therapeutics

Adam Schafer et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein

Febrina Meutiawati et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection

Adrian Oo et al.

ANTIVIRAL RESEARCH (2018)

Article Pharmacology & Pharmacy

The molecular tweezer CLR01 inhibits Ebola and Zika virus infection

Annika E. Roecker et al.

ANTIVIRAL RESEARCH (2018)

Article Chemistry, Medicinal

Identification of novel small-molecule inhibitors of Zika virus infection

Ewa D. Micewicz et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Chemistry, Medicinal

Recent applications of machine learning in medicinal chemistry

Jane Panteleev et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Medicinal

Niclosamide, a Drug with Many (Re)purposes

Hachemi Kadri et al.

CHEMMEDCHEM (2018)

Review Pharmacology & Pharmacy

The A-Z of Zika drug discovery

Melina Mottin et al.

DRUG DISCOVERY TODAY (2018)

Review Pharmacology & Pharmacy

A bibliometric review of drug repurposing

Nancy C. Baker et al.

DRUG DISCOVERY TODAY (2018)

Review Pharmacology & Pharmacy

The rise of deep learning in drug discovery

Hongming Chen et al.

DRUG DISCOVERY TODAY (2018)

Article Virology

The antimalarial drug amodiaquine possesses anti-ZIKA virus activities

Yingshan Han et al.

JOURNAL OF MEDICAL VIROLOGY (2018)

Article Chemistry, Medicinal

Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors

Stephen J. Capuzzi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Drug Repurposing for Viral Infectious Diseases: How Far Are We?

Beatrice Mercorelli et al.

TRENDS IN MICROBIOLOGY (2018)

Article Virology

The antimicrobial peptide HS-1 inhibits dengue virus infection

Juliana M. C. Monteiro et al.

VIROLOGY (2018)

Article Parasitology

High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth

Gregory D. Bowden et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2018)

Review Public, Environmental & Occupational Health

Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome(MERS): A review

Sabeena Mustafa et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2018)

Review Biochemistry & Molecular Biology

Review of Drug Repositioning Approaches and Resources

Hanqing Xue et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Biochemical Research Methods

Computational drug repurposing to predict approved and novel drug-disease associations

Zoya Khalid et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2018)

Article Virology

Drug repurposing of quinine as antiviral against dengue virus infection

Shilu Malakar et al.

VIRUS RESEARCH (2018)

Article Chemistry, Multidisciplinary

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease

Ankur Kumar et al.

ACS OMEGA (2018)

Article Nanoscience & Nanotechnology

Anisotropic Gold Nanostructures: Optimization via in Silico Modeling for Hyperthermia

Ajay Vikram Singh et al.

ACS APPLIED NANO MATERIALS (2018)

Article Biochemistry & Molecular Biology

Sofosbuvir as treatment against dengue?

Chye Sheng Gan et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2018)

Review Pharmacology & Pharmacy

Drug repurposing screens and synergistic drug-combinations for infectious diseases

Wei Zheng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Infectious Diseases

The thiopurine nucleoside analogue 6-methylmercaptopurine riboside (6MMPr) effectively blocks Zika virus replication

Otavio Valerio de Carvalho et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)

Article Biochemistry & Molecular Biology

Epigallocatechin gallate, an active green tea compound inhibits the Zika virus entry into host cells via binding the envelope protein

Nitin Sharma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Article Infectious Diseases

Sofosbuvir: an antiviral drug with potential efficacy against Zika infection

Sandra E. Reznik et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2017)

Article Chemistry, Medicinal

Synthetic Approaches to the New Drugs Approved During 2015

Andrew C. Flick et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Pharmacology & Pharmacy

The FDA-approved drug sofosbuvir inhibits Zika virus infection

Kristen M. Bullard-Feibelman et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

The natural compound silvestrol is a potent inhibitor of Ebola virus replication

Nadine Biedenkopf et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus

Anuradha Balasubramanian et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus

Jared D. Pitts et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Cell-line dependent antiviral activity of sofosbuvir against Zika virus

Noreen Mumtaz et al.

ANTIVIRAL RESEARCH (2017)

Review Food Science & Technology

Curcumin: A Review of Its Effects on Human Health

Susan J. Hewlings et al.

FOODS (2017)

Article Biochemistry & Molecular Biology

Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus

Jeng-Wei Lu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

The medicinal chemistry of Chikungunya virus

Edeildo F. da Silva-Junior et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

Article Pharmacology & Pharmacy

Polysulfonate suramin inhibits Zika virus infection

Chee Wah Tan et al.

ANTIVIRAL RESEARCH (2017)

Review Medicine, Research & Experimental

Recent trends in ZikV research: A step away from cure

Aftab Alam et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Chemistry, Medicinal

Flex-nucleoside analogues - Novel therapeutics against filoviruses

Mary K. Yates et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Medicinal

Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies

Tao Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Medical Laboratory Technology

Chikungunya Virus

David M. Vu et al.

CLINICS IN LABORATORY MEDICINE (2017)

Article Pharmacology & Pharmacy

Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding

Bryan C. Mounce et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor

Jasper Fuk-Woo Chan et al.

ANTIVIRAL RESEARCH (2017)

Review Pharmacology & Pharmacy

Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle

Baptiste Martin et al.

ANTIVIRAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Activity of andrographolide against dengue virus

Patcharee Panraksa et al.

ANTIVIRAL RESEARCH (2017)

Review Chemistry, Organic

Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment

Kunisuke Izawa et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2016)

Review Pharmacology & Pharmacy

Bioengineered and biohybrid bacteria-based systems for drug delivery

Zeinab Hosseinidoust et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Pharmacology & Pharmacy

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

Finny S. Varghese et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses

Margot Carocci et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Antiviral effect of ranpirnase against Ebola virus

Thomas Hodge et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Suramin treatment reduces chikungunya pathogenesis in mice

Szu-Cheng Kuo et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Antiviral activity of selected flavonoids against Chikungunya virus

Rafidah Lani et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Novel antiviral activity of bromocriptine against dengue virus replication

Fumihiro Kato et al.

ANTIVIRAL RESEARCH (2016)

Article Pharmacology & Pharmacy

Teicoplanin inhibits Ebola pseudovirus infection in cell culture

Yizhuo Wang et al.

ANTIVIRAL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Drug repurposing of minocycline against dengue virus infection

Shilpa Lekshmi Leela et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Microbiology

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Nicholas J. Barrows et al.

CELL HOST & MICROBE (2016)

Article Automation & Control Systems

Adefovir dipivoxil - A possible regimen for the treatment of dengue virus (DENV) infection

Sukesh Narayan Sinha et al.

CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS (2016)

Article Pharmacology & Pharmacy

Antiviral therapeutics for the treatment of Ebola virus infection

Anthony P. Cardile et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

Article Chemistry, Medicinal

Discovery of antiviral molecules for dengue: In silico search and biological evaluation

Maria Cabarcas-Montalvo et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

The Medicinal Chemistry of Dengue Virus

Mira A. M. Behnam et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Chemistry, Organic

Drug Repositioning An Approach for Drug Discovery

Parin K. Vora et al.

MINI-REVIEWS IN ORGANIC CHEMISTRY (2016)

Article Virology

The green tea molecule EGCG inhibits Zika virus entry

Bruno M. Carneiro et al.

VIROLOGY (2016)

Article Public, Environmental & Occupational Health

Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus

Jean-Francois Rossingol

JOURNAL OF INFECTION AND PUBLIC HEALTH (2016)

Review Biochemistry & Molecular Biology

Computational approaches in target identification and drug discovery

Theodora Katsila et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2016)

Article Pharmacology & Pharmacy

The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection

Christopher Weber et al.

ANTIVIRAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Suramin inhibits chikungunya virus replication through multiple mechanisms

Irina C. Albulescu et al.

ANTIVIRAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Ebola virus dynamics in mice treated with favipiravir

Vincent Madelain et al.

ANTIVIRAL RESEARCH (2015)

Article Pharmacology & Pharmacy

Inhibition of dengue virus production and cytokine/chemokine expression by ribavirin and compound A

Thidarath Rattanaburee et al.

ANTIVIRAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

Lorena Ramos Freitas de Sousa et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Meeting Abstract Pharmacology & Pharmacy

HIGH DOSE FAVIPIRAVIR: FIRST EXPERIENCE IN A PATIENT WITH EBOLA

A. M. Borobia et al.

CLINICAL THERAPEUTICS (2015)

Letter Cardiac & Cardiovascular Systems

Ebola therapy: Developing new drugs or repurposing old ones?

Giovanni Lentini et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

Letter Medicine, General & Internal

Favipiravir-a prophylactic treatment for Ebola contacts?

Michel Van Herp et al.

LANCET (2015)

Letter Medicine, General & Internal

Favipiravir for children with Ebola

Naim Bouazza et al.

LANCET (2015)

Review Chemistry, Medicinal

Development of Small-Molecule Antivirals for Ebola

Zlatko Janeba

MEDICINAL RESEARCH REVIEWS (2015)

Article Biochemical Research Methods

Hierarchical virtual screening approaches in small molecule drug discovery

Ashutosh Kumar et al.

METHODS (2015)

Article Immunology

Development of therapeutics for treatment of Ebola virus infection

Haoyang Li et al.

MICROBES AND INFECTION (2015)

Editorial Material Chemistry, Medicinal

Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens

Jeanne M. Sisk et al.

ACS INFECTIOUS DISEASES (2015)

Article Chemistry, Medicinal

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

Peter B. Madrid et al.

ACS INFECTIOUS DISEASES (2015)

Article Multidisciplinary Sciences

Suramin Inhibits Chikungunya Virus Entry and Transmission

Yi-Jung Ho et al.

PLOS ONE (2015)

Article Pharmacology & Pharmacy

Antiviral activity of lanatoside C against dengue virus infection

Yan Yi Cheung et al.

ANTIVIRAL RESEARCH (2014)

Article Pharmacology & Pharmacy

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

Lisa Oestereich et al.

ANTIVIRAL RESEARCH (2014)

Article Pharmacology & Pharmacy

Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus

Ruben Soto-Acosta et al.

ANTIVIRAL RESEARCH (2014)

Article Pharmacology & Pharmacy

Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity

Siwaporn Boonyasuppayakorn et al.

ANTIVIRAL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

Chandrakala Basavannacharya et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Letter Cardiac & Cardiovascular Systems

Ebola: Is there a hope from treatment with cardiovascular drugs?

Salvatore Patane

INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)

Article Infectious Diseases

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

Jaffar A. Al-Tawfiq et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2014)

Article Chemistry, Medicinal

Chikungunya Virus: Emerging Targets and New Opportunities for Medicinal Chemistry

Adel A. Rashad et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

News Item Multidisciplinary Sciences

The long battle to find a cure for Ebola

Clare Wilson

NEW SCIENTIST (2014)

Article Virology

Antiviral drugs specific for coronaviruses in preclinical development

Adeyemi O. Adedeji et al.

CURRENT OPINION IN VIROLOGY (2014)

Review Pharmacology & Pharmacy

Ten years of dengue drug discovery: Progress and prospects

Siew Pheng Lim et al.

ANTIVIRAL RESEARCH (2013)

Article Infectious Diseases

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

Jasper F. W. Chan et al.

JOURNAL OF INFECTION (2013)

Article Chemistry, Medicinal

Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13

Mi-Sun Yu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Review Clinical Neurology

Emerging Viral Infections

James F. Bale

SEMINARS IN PEDIATRIC NEUROLOGY (2012)

Article Pharmacology & Pharmacy

Emodin inhibits current through SARS-associated coronavirus 3a protein

Silvia Schwarz et al.

ANTIVIRAL RESEARCH (2011)

Article Pharmacology & Pharmacy

Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein

Daisuke Kato et al.

ANTIVIRAL RESEARCH (2010)

Review Pharmacology & Pharmacy

Pharmacophore modeling and applications in drug discovery: challenges and recent advances

Sheng-Yong Yang

DRUG DISCOVERY TODAY (2010)

Article Pharmacology & Pharmacy

Antiviral activity of geneticin against dengue virus

Xianchao G. Zhang et al.

ANTIVIRAL RESEARCH (2009)

Review Pharmacology & Pharmacy

Homology modeling in drug discovery: current trends and applications

Claudio N. Cavasotto et al.

DRUG DISCOVERY TODAY (2009)

Review Immunology

Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?

Umesh C. Chaturvedi et al.

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2009)

Article Chemistry, Medicinal

How To Optimize Shape-Based Virtual Screening: Choosing the Right Query and Including Chemical Information

Johannes Kirchmair et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)

Review Chemistry, Medicinal

The Medicinal Chemistry of Dengue Fever

Andrew J. Stevens et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Review Pharmacology & Pharmacy

Molecule-pharmacophore superpositioning and pattern matching in computational drug design

Gerhard Wolber et al.

DRUG DISCOVERY TODAY (2008)

Article Public, Environmental & Occupational Health

On Chikungunya Acute Infection and Chloroquine Treatment

Xavier De Lamballerie et al.

VECTOR-BORNE AND ZOONOTIC DISEASES (2008)

Article Chemistry, Multidisciplinary

The search for a structural basis for therapeutic intervention against the SARS coronavirus

Bartlam Mark et al.

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2008)

Article Biochemistry & Molecular Biology

Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease

YC Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Biochemistry & Molecular Biology

Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines

B Morgenstern et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Chemistry, Medicinal

Generation of predictive pharmacophore model for SARS-coronavirus main proteinase

XW Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Chemistry, Medicinal

Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase

ZM Liu et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

Article Biochemistry & Molecular Biology

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

N Yamamoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

E Keyaerts et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

JE Blanchard et al.

CHEMISTRY & BIOLOGY (2004)

Review Biochemical Research Methods

Emerging viral infections in a rapidly changing world

T Kuiken et al.

CURRENT OPINION IN BIOTECHNOLOGY (2003)