Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 61, Issue 14, Pages 2399-2410Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2020.1777932
Keywords
Arachidonic acid; prostaglandins; leukotrienes; cell proliferation; differentiation; innate immunity; intestinal epithelial barrier
Categories
Funding
- National Key Research and Development Project of China [2017YFD0500503]
- Fundamental Research Funds for the Central Universities of China [2662019YJ006]
- Hubei Agricultural Sciences and Technology Innovation Center [2019ABA081]
- Hubei Provincial Creative Team Project [2016-620-000001-043]
Ask authors/readers for more resources
ARA plays a significant role in growth and development, while its release can lead to the production of eicosanoids, which have various physiological functions.
Arachidonic acid (ARA), an n-6 essential fatty acid, plays an important role in human and animal growth and development. The ARA presents in the membrane phospholipids can be released by phospholipase A2. These free arachidonic acid molecules are then used to produce eicosanoids through three different pathways. Previous studies have demonstrated that eicosanoids have a wide range of physiological functions. Although they are generally considered to be pro-inflammatory molecules, recent advances have elucidated they have an effect on innate immunity via regulating the development, and differentiation of innate immune cells and the function of the intestinal epithelial barrier. Here, we review eicosanoids generation in intestine and their role in intestinal innate immunity, focusing on intestinal epithelial barrier, innate immune cell in lamina propria (LP) and their crosstalk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
