Journal
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
Volume 52, Issue 1, Pages 170-193Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2020.1791044
Keywords
Biosensing; chemoselective ligation; detection
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Funding
- National Natural Science Foundation of China [31671923]
- Shanghai Pujiang Program [18PJD016]
- Science and Technology Commission of Shanghai Municipality [20392001800]
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This review summarizes the roles of chemoselective ligations in biosensor construction and reviews their applications in detecting various targets. Furthermore, the future development trends of these reactions in biosensing are discussed.
With the advantages of mild reaction condition as well as high stereoselectivity and efficiency, chemoselective ligations including oxime chemistry, hydrazone chemistry, cycloaddition reaction, C-C multiple bond addition reaction, nucleophilic rings opening reaction, and alkynes-based reaction, have been applied in the field of biosensing. In this review, the roles of these chemoselective ligations for the construction of biosensors have been summarized. The ligations can serve for reactant preparation, interface modification, signal probe synthesis, molecular recognition, signal amplification, and output. Meanwhile, their recent applications for detection of various targets including small molecules, metal ions, protein, and nucleic acid so on, have been reviewed. Moreover, the development trend of these ligations in biosensing has also been prospected in this review.
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