Journal
COORDINATION CHEMISTRY REVIEWS
Volume 412, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2020.213259
Keywords
Non-steroidal anti-inflammatory drugs; Copper(II) complexes; Zinc(II) complexes; Structure; Biological activity
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Funding
- European Social Fund (ESF)
- Greek national funds (National Strategic Reference Framework (NSRF))
- Greek national funds (General Secretariat for Research and Technology (GSRT) Hellenic Foundation for Research and Innovation (HFRI))
- Greek national funds (Greek Ministry of Education, Research and Religion)
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Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic, anti-inflammatory and antipyretic agents with known side-effects. The most important NSAIDs are carboxylate derivatives of phenylalkanoic acids, anthranilic acid and salicylic acid. In most cases, the metal complexes of NSAID ligands are more active as drugs than the corresponding free NSAIDs. The structural features concerning the sofar reported NSAID complexes with copper(II) or zinc(II) are presented. In addition, the in vitro antioxidant activity of these compounds (radical scavenging, soybean lipoxygenase inhibition and superoxide dismutase mimicking activity) is discussed. (C) 2020 Elsevier B.V. All rights reserved.
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