Journal
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
Volume 19, Issue 4, Pages 1488-1520Publisher
WILEY
DOI: 10.1111/1541-4337.12578
Keywords
bioactive peptides; digestion; hydrolysis; peptide identification; peptidomics; systematic review
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Funding
- Shahid Beheshti University of Medical Sciences
- Cardiovascular Research Center of Tabriz University of Medical Sciences
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Due to the digestible refractory and absorbable structures of bioactive peptides (BPs), they could induce notable biological impacts on the living organism. In this regard, the current study was devoted to providing an overview regarding the available methods for BPs generation by the aid of a systematic review conducted on the published articles up to April 2019. In this context, the PubMed and Scopus databases were screened to retrieve the related publications. According to the results, although the characterization of BPs mainly has been performed using enzymatic and microbialin-vitromethods, they cannot be considered as suitable techniques for further stimulation of digestion in the gastrointestinal tract. Therefore, new approaches for bothin-vivoandin-silicomethods for BPs identification should be developed to overcome the obstacles that belonged to the current methods. The purpose of this review was to compile the recent analytical methods applied for studying various aspects of food-derived biopeptides, and emphasizing generation atin vitro,in vivo, andin silico.
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