Journal
COMPLEMENTARY THERAPIES IN MEDICINE
Volume 51, Issue -, Pages -Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ctim.2020.102397
Keywords
Plantago major L.; Mucositis; Cancer; Herbal medicine; Persian medicine; Clinical trial
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Funding
- Arak University of Medical Sciences
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Introduction: Oral mucositis is a complication of radiation therapy in cancer patients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancer patients. Methods: In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23 patients received placebo syrup as control group for 7 weeks. Outcome measures were severity of mucositis according to WHO scale and severity of patients' pain assessed by visual analogue scale. Results: Severity of mucositis were significantly lower in intervention group compared to placebo group (p value < 0.05). Also patients in intervention group experienced significantly less pain compared to placebo group during radiotherapy period (p value < 0.05) Conclusion: Plantago major L syrup was effective on the reduction of the symptoms of radiation induced mucositis in patients with head and neck cancers.
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