Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 191, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.110996
Keywords
magnesium; biomaterial; infection; bacteria
Funding
- Junta de Extremadura [GR15089, GR18153, GR15025, GR18096, IB16117, IB16154]
- FEDER [GR15089, GR18153, GR15025, GR18096, IB16117, IB16154]
- Ministerio de Economia y Competitividad del Gobierno de Espana [MAT201563974-C4-3-R, MAT2015-63974-C4-4-R PCIN-2016-146, RTI2018096862-B-I00]
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Magnesium is currently increasing interest in the field of biomaterials. An extensive bibliography on this material in the last two decades arises from its potential for the development of biodegradable implants. In addition, many researches, motivated by this progress, have analyzed the performance of magnesium in both in vitro and in vivo assays with gram-positive and gram-negative bacteria in a very broad range of conditions. This review explores the extensive literature in recent years on magnesium in biomaterials-related infections, and discusses the mechanisms of the Mg action on bacteria, as well as the competition of Mg2+ and/or synergy with other divalent cations in this subject.
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