Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 191, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111013
Keywords
Cerium oxide nanoparticles; Antioxidants; Photochemoprotection; UVB; Fibroblasts
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior CAPES)
- Programa de Apoio a Nucleos de Excelencia (PRONEX)/Fundacao Araucaria
- Complexo de Centrais de Apoio a Pesquisa (COMCAP)Universidade Estadual de Maringa
- NSF (National Science Foundation) MRI XPS: ECCS (Electrical, Communications and Cyber Systems) [1726636]
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1726636] Funding Source: National Science Foundation
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The Ultraviolet-B radiation (UVB) might induce cellular redox imbalance which plays an important role in the development of skin disorders. Thus, the search for photochemoprotective alternatives with antioxidant efficacy would be a safe aspect towards prevention of skin diseases. Cerium oxide nanoparticles (CNPs) have antioxidant properties, that are mostly related to CNPs catalase and superoxide dismutase (SOD)-like antioxidative mimetic activity. Considering that, we investigated whether CNPs induce photochemoprotection against UVB-induced cellular damages on L929 fibroblasts. Our results showed that CNPs prevented UVB mediated L929 cell oxidative damage by reestablishing the oxidative balance through ameliorating the reactive oxygen species (ROS) level and enhancing the antioxidant enzyme activities.
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