Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 606, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2020.125394
Keywords
PEG nanoparticles; Mesoporous silica templating; Cell targeting; Low-fouling; Photodynamic therapy
Categories
Funding
- National Natural Science Foundation of China [21872085, 21603120]
- Translational Medicine Core Facility of Advanced Medical Research Institute at Shandong University
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A challenge for nanomedicine is to improve their targeting ability and avoid nonspecific interactions with the surrounding environments. Herein, we report the fabrication of photosensitizer-loaded poly(ethylene glycol) nanoparticles (PEG NPs) with high targeting ability to inhibit cancer cell growth. PEG NPs are prepared via a mesoporous silica (MS) templating method and functionalized with cyclic Arg-Gly-Asp (RGD) peptides for specific targeting to U87 MG cells expressed with alpha(v)beta(3) integrins. Chlorin e6 (Ce6) as a photosensitizer is conjugated onto PEG and encapsulated into PEG NPs for photodynamic therapy (PDT). The obtained PEG-Ce6-RGD NPs can efficiently target to U87 MG cells and improve the PDT efficacy. Our approach provides an avenue to engineer targeted polymer carriers for PDT.
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