Journal
CLINICAL TRIALS
Volume 17, Issue 5, Pages 562-566Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1740774520941419
Keywords
Multiple testing; multi-arm clinical trial; family-wise error rate; type-I error; multiplicity; alpha adjustment
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Funding
- NHS Lothian via the Edinburgh Clinical Trials Unit
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There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
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