Journal
CLINICAL TRANSPLANTATION
Volume 34, Issue 10, Pages -Publisher
WILEY
DOI: 10.1111/ctr.14021
Keywords
hypogammaglobulinemia; pediatric solid organ transplant
Categories
Funding
- ALSAC
- NIH NCI [NIH NCI P30 CA21765]
- Albert Einstein College of Medicine/Montefiore Medical Center Department of Pediatrics
Ask authors/readers for more resources
Introduction Hypogammaglobulinemia has not been well studied in pediatric solid organ transplant (SOT) recipients. We evaluated plasma immunoglobulin (Ig) and lymphocyte phenotypes among 31 pediatric heart and kidney recipients for two years post-transplant and from 10 non-transplanted children. Methods Plasma IgM, IgG, and IgA were quantified by immunoturbidimetric assays, IgG subclasses were quantified by bead-based multiplex immunoassay, and lymphocyte phenotypes were assessed by flow cytometry. Results Median age at transplant for SOT recipients was similar to that of the control cohort (15 vs. 12.5 years, respectively;P = .61). Mean plasma IgG and IgM levels for SOT recipients fell significantly below the control cohort means by 1 month post-transplant (P < .001 for both) and remained lower than control levels at 12-18 months post-transplant. Heart recipients had lower frequencies of a CD4(+)naive T lymphocytes relative to kidney recipients. Conclusions Hypogammaglobulinemia was prevalent and persistent among pediatric SOT recipients and may be secondary to immunosuppressive medications, as well as loss of thymus tissue and CD45RA(+) CD4(+)T cells in heart recipients. Limitations of our study include but are not limited to small sample size from a single center, lack of samples for all participants at every time point, and lack of peripheral blood mononuclear cell samples for the non-transplanted cohort.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available