Journal
CLINICAL PHARMACOKINETICS
Volume 60, Issue 1, Pages 69-77Publisher
ADIS INT LTD
DOI: 10.1007/s40262-020-00910-1
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- Roche
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This study showed that milk with 3.9% fat has no effect on erlotinib exposure in NSCLC patients, regardless of PPI use, and the combination with milk is safe and well tolerated. Concurrent treatment with esomeprazole significantly reduces both the AUC and Cmax of erlotinib, and should be avoided if possible.
Introduction Erlotinib's gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to increase erlotinib uptake. We performed a two-period, randomized, crossover study to investigate the influence of cow's milk with 3.9% fat on the exposure of erlotinib with and without the PPI esomeprazole in patients with non-small cell lung cancer (NSCLC). The effect of esomeprazole was studied in an additional intrapatient comparison. Method Pharmacokinetic sampling was performed on days 7 and 14 during 24 consecutive hours. During the 7 days prior to pharmacokinetic sampling, erlotinib was taken daily with 250 mL of either water or milk. In the PPI arm, esomeprazole (40 mg once daily 3 h prior to erlotinib) was taken for 3 days. Results Erlotinib area under the curve from time zero to 24 h (AUC(24)) did not significantly change when administered with milk, compared with water, in both non-PPI users (n = 14; - 3%; 95% confidence interval [CI] - 12 to 8%;p = 0.57) and patients who used esomeprazole (n = 15; 0%; 95% CI - 15 to 17%;p = 0.95). Esomeprazole decreased erlotinib AUC(24)by 47% (n = 9; 95% CI - 57 to - 34%;p < 0.001) andC(max)by 56% (95% CI - 64 to - 46%;p < 0.001). No differences in toxicities were observed between milk and water. Conclusion Milk with 3.9% fat has no effect on the exposure to erlotinib in NSCLC patients, independent of PPI use. The combination with milk is safe and well tolerated. Concomitant esomeprazole treatment strongly decreased both erlotinib AUC(24)andC(max)and should be avoided if possible.
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